产品货号：
Z11403
中文名称：
Aurora A/AURKA抗体
英文名称：
Anti-Aurora A/AURKA Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Aurora A/AURKA Antibody |
| 指标别名 | AIK;ARK 1;ARK1;AURA;AURKA;Aurora A;aurora kinase A;Aurora related kinase 1;Aurora/IPL1 related kinase 1;AURORA2;Breast tumor amplified kinase;BTAK;hARK1;STK15;STK6;STK7 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | AURKA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Aurora A/AURKA recombinant protein (Position:M1-K97). |
| 实际分子量 | 46KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | AURKA(aurora kinase A),also called ARK1,AurA,AIK,AURORA2,BTAK,PPP1R47,STK7,STK15,STK6,is a mitotic centrosomal protein kinase.The main role of AURKA in tumor development is in controlling chromosome segregation during mitosis.Aurora A is a member of a family of mitotic serine/threonine kinases.Cell cycle and Northern blot analyses showed that peak expression of AURKA occurs during the G2/M phase and then decreases.By fluorescence in situ hybridization,AURKA gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42.The AURKA gene is overexpressed in many human cancers.Ectopic overexpression of Aurora kinase A in mammalian cells induces centrosome amplification,chromosome instability,and oncogenic transformation,a phenotype characteristic of loss-of-function mutations of p53.Depletion of Ajuba prevented activation of AURKA at centrosomes in late G2 phase and inhibited mitotic entry.Activation of AURKA was independently sufficient to induce rapid ciliary resorption,and AURKA acted in this process through phosphorylation of HDAC6,leading to HDAC6-dependent tubulin deacetylation and destabilization of the ciliary axoneme.Small molecule inhibitors of AURKA and HDAC6 reduced regulated disassembly of cilia. |
| Uniprot ID | O14965 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | aurora kinase A |
| 蛋白名全称 | Aurora kinase A |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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